{"id":1794,"date":"2020-08-26T08:00:29","date_gmt":"2020-08-26T08:00:29","guid":{"rendered":"http:\/\/emultrasound.sdsc.edu\/?p=1794"},"modified":"2021-05-04T16:56:32","modified_gmt":"2021-05-04T16:56:32","slug":"ivc-collapsibility","status":"publish","type":"post","link":"https:\/\/emultrasound.ucsd.edu\/index.php\/2020\/08\/26\/ivc-collapsibility\/","title":{"rendered":"Can IVC collapsibility predict fluid responsiveness in non-ventilated patients?"},"content":{"rendered":"<div class=\"mp-row-fluid motopress-row mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-clmn mp-span12  mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-text-obj\">\n<h2 style=\"text-align: center;\">Background<\/h2>\n<p dir=\"ltr\">Fluid responsiveness is key in guiding the resuscitation of critically ill patients, and both under and over resuscitation can lead to poor clinical outcomes. Vitals and physical exam are not always reliable in determining fluid responsiveness. The search for a quick, easy and accurate diagnostic test to determine fluid responsiveness is ongoing. IVC collapsibility (cIVC) has been proposed as a helpful measure, and in ventilated patients this measurement has been validated. However, spontaneously breathing patients have different physiology, so it is unclear if cIVC is an accurate predictor of fluid responsiveness in this cohort. Previous studies have recommended a cIVC cutoff of 40-42% as a reliable predictor of fluid responsiveness in spontaneously breathing patients (1,2). This study sought to validate those findings.&nbsp;<\/p>\n<p dir=\"ltr\">&nbsp;<\/p>\n<p dir=\"ltr\"><a class=\"\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28525778\/\">Inferior vena cava collapsibility detects fluid responsiveness among spontaneously breathing critically-ill patients<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mp-row-fluid motopress-row mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-clmn mp-span12  mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-accordion-obj motopress-accordion motopress-accordion-dark\" data-atts=\"{&quot;active&quot;:&quot;false&quot;,&quot;collapsible&quot;:true,&quot;header&quot;:&quot;&gt; div &gt; h3&quot;,&quot;heightStyle&quot;:&quot;content&quot;}\">\n<div class=\"motopress-accordion-item\"><h3>Clinical Question<\/h3><div>\n<p><span style=\"font-weight: 400;\">Can the collapsibility of the inferior vena cava differentiate between fluid responders and fluid non-responders in non-ventilated critically ill patients?<\/span><\/p>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>Methods & Study Design<\/h3><div>\n<p class=\"p1\"><span class=\"s1\"><b>\u2022 Design\u00a0<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">This was a prospective observational trial.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u2022 Population\u00a0<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Inclusion: spontaneously breathing patients with signs of acute circulatory failure in the ED and ICU of 2 academic hospitals in the US. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Exclusion: primary traumatic, cardiogenic, obstructive, or neurogenic shock; age < 18 years old; incarceration; pregnancy; and\/or hospitalization for >36 h; NIPPV; if the clinical team felt that they had active pulmonary edema; or that believed that further IVFs might pose a clinical risk.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u2022 Intervention\u00a0<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">A NICOM device monitored cardiac index at 1 minute intervals for the duration of the study. Patients had initial cardiac index measurements and IVC videos recorded. Then, after a 3 minute passive leg raise, an additional IVC video was recorded. Lastly, patients received a 500ml normal saline bolus and immediately had a final IVC video recorded. Images were reviewed after the study to determine the cIVC.\u00a0<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span class=\"s1\"><b>\u2022 Outcomes\u00a0\u00a0<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The primary outcome was fluid responsiveness, defined as a \u2265 10% increase in cardiac index.<\/span><\/p>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>Results<\/h3><div>\n<p><span style=\"font-weight: 400;\">A cIVC of 25% provided maximum sensitivity (87%) and specificity (81%) in identifying fluid responders. However, as you can see in the figure below, there were several patients with cIVC below 25% who\u00a0<em>were<\/em> fluid responders, and several patients with cIVC above 25% who\u00a0<em>were not<\/em> fluid responders.\u00a0<\/span><\/p>\n<figure id=\"attachment_1796\" aria-describedby=\"caption-attachment-1796\" style=\"width: 643px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1796\" src=\"https:\/\/i0.wp.com\/emultrasound.sdsc.edu\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-24-at-1.00.27-PM.png?resize=525%2C380\" alt=\"IVC fluid responder\" width=\"525\" height=\"380\" srcset=\"https:\/\/i0.wp.com\/emultrasound.ucsd.edu\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-24-at-1.00.27-PM.png?w=643&amp;ssl=1 643w, https:\/\/i0.wp.com\/emultrasound.ucsd.edu\/wp-content\/uploads\/2020\/08\/Screen-Shot-2020-08-24-at-1.00.27-PM.png?resize=300%2C217&amp;ssl=1 300w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" \/><figcaption id=\"caption-attachment-1796\" class=\"wp-caption-text\">Corl et al.<\/figcaption><\/figure>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>Strength & Limitations<\/h3><div>\n<p><span style=\"font-weight: 400;\">Strengths: The prospective study design reduces bias and confounding factors. Few studies have examined fluid responsiveness in non-ventilated patients, and this adds to the growing body of evidence in this population.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Limitations: This study primarily included patients with severe sepsis\/septic shock and DKA\/HHS. This limits the generalizability of the findings to other forms of acute circulatory failure. Furthermore, fluid responsiveness was measured once immediately following the bolus. Monitoring the patients\u2019 clinical status over several hours or for the duration of the ICU admission may have provided additional, clinically relevant data regarding fluid resuscitation. <\/span><\/p>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>Authors Conclusion<\/h3><div>\n<p><span style=\"font-weight: 400;\">\u201ccIVC, as measured by POCUS, is able to detect fluid responsiveness and may be used to guide IVF resuscitation among spontaneously breathing critically-ill patients.\u201d<\/span><\/p>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>Our Conclusion<\/h3><div>\n<p><span style=\"font-weight: 400;\">In spontaneously breathing patients with distributive shock, cIVC can be a useful tool in identifying fluid responsiveness, with the caveat that a minority of patients with minimal IVC collapsibility may still be fluid responders and those with significant IVC collapsibility may not be fluid responders. There is certainly a trend toward a collapsible IVC identifying fluid responders, but the outliers in this study should be taken into account. IVC, along with history, exam and bedside echo, can be used to identify which patients may need more IV fluid resuscitation.\u00a0<\/span><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mp-row-fluid motopress-row mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-clmn mp-span12  mpce-prvt-1570-5ef827785bcec mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-text-obj\">\n<h1 style=\"text-align: center;\">The Bottom Line&nbsp;<\/h1>\n<p dir=\"ltr\">IVC collapsibility >25% predicts fluid responsiveness in spontaneously breathing patients with distributive shock <em>most of the time<\/em>, but should not be solely relied upon.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mp-row-fluid motopress-row mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-clmn mp-span12  mpce-dsbl-margin-left mpce-dsbl-margin-right\">\n<div class=\"motopress-accordion-obj motopress-accordion motopress-accordion-dark\" data-atts=\"{&quot;active&quot;:&quot;false&quot;,&quot;collapsible&quot;:true,&quot;header&quot;:&quot;&gt; div &gt; h3&quot;,&quot;heightStyle&quot;:&quot;content&quot;}\">\n<div class=\"motopress-accordion-item\"><h3>Authors<\/h3><div>\n<p>This post was written by Aaser Ali, MS4 at UCSD School of Medicine, Charles Murchison, MD and Amir Aminlari, MD.\u00a0<\/p>\n<\/div><\/div>\n<div class=\"motopress-accordion-item\"><h3>References <\/h3><div>\n<ol>\n<li>\n<p><span style=\"font-weight: 400;\">Corl KA, George NR, Romanoff J, et al. Inferior vena cava collapsibility detects fluid responsiveness among spontaneously breathing critically-ill patients. J Crit Care. 2017;41:130-137.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Machare-Delgado E, Decaro M, Marik PE. Inferior vena cava variation compared to<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">pulse contour analysis as predictors of fluid responsiveness: a prospective cohort<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">study. Intensive Care Med 2011;26(2):116\u201324.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Muller L, Bobbia X, Toumi M, et al. Respiratory variations of inferior vena cava diam-<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">eter to predict fluid responsiveness in spontaneously breathing patients with acute<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">circulatory failure: need for a cautious use. Crit Care 2012;16(5):R188.<\/span><\/p>\n<\/li>\n<\/ol>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"Background Fluid responsiveness is key in guiding the resuscitation of critically ill patients, and both under and over resuscitation can lead to poor clinical outcomes. Vitals and physical exam are not always reliable in determining fluid responsiveness. The search for a quick, easy and accurate diagnostic test to determine fluid responsiveness is ongoing. IVC collapsibility &hellip; <p class=\"link-more\"><a href=\"https:\/\/emultrasound.ucsd.edu\/index.php\/2020\/08\/26\/ivc-collapsibility\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> \"Can IVC collapsibility predict fluid responsiveness in non-ventilated patients?\"<\/span><\/a><\/p>","protected":false},"author":2,"featured_media":1799,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[5],"tags":[75,74],"class_list":["post-1794","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-journal-club","tag-fluid-responsiveness","tag-ivc-ultrasound"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can IVC collapsibility predict fluid responsiveness in non-ventilated patients? - UCSD Ultrasound<\/title>\n<meta name=\"description\" content=\"What is the most sensitive view in the FAST exam? 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